Chemical Analysis of Single Cells

In this Review, we provide an overview of methods developed for chemical analysis of single cells over the last two years. Many biological systems contain an ensemble of cells with heterogeneous chemistry; therefore, it is important to analyze them on an individual basis in order to elucidate the ro...

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Bibliographic Details
Published inAnalytical chemistry (Washington) Vol. 85; no. 2; pp. 522 - 542
Main Authors Trouillon, Raphaël, Passarelli, Melissa K, Wang, Jun, Kurczy, Michael E, Ewing, Andrew G
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 15.01.2013
Subjects
Analytical Chemistry
Analytisk kemi
Animals
droplet microfluidics
Electrochemical Techniques
Fluorescent Dyes - chemistry
fluorescent protein
Humans
in-vivo
ion mass-spectrometry
Lab-On-A-Chip Devices
living cells
Mass Spectrometry
Microscopy, Fluorescence
multifunctional pipette
neuroendocrine cells
oxygen
reactive
sample preparation
scanning electrochemical microscopy
Single-Cell Analysis
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Summary:In this Review, we provide an overview of methods developed for chemical analysis of single cells over the last two years. Many biological systems contain an ensemble of cells with heterogeneous chemistry; therefore, it is important to analyze them on an individual basis in order to elucidate the role each cell plays in the function of these systems. In clinical diagnostics, the development of extremely sensitive measurements, down to single cells, may provide the best ability for diagnoses. Single cell analysis has, in fact, been present for quite some time. Investigators in life sciences consider the cell as the unit of life and so the pursuit to quantify, image, and modulate the cell has been ongoing for decades.
Bibliography:ObjectType-Article-1
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ISSN:0003-2700
1520-6882
1520-6882
DOI:10.1021/ac303290s