Mechanism of Activation and Inactivation of Gq/Phospholipase C-β Signaling Nodes

• Published in: Chemical reviews Vol. 111; no. 10; pp. 6120 - 6129
• Main Authors: Harden, T. Kendall, Waldo, Gary L, Hicks, Stephanie N, Sondek, John
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.10.2011
• Subjects: Activation; Animals; Biocatalysis; Enzymes; GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry; GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism; Guanosine Triphosphate - metabolism; Hardening; Humans; Hydrolysis; Inactivation; Lipid Metabolism; Phospholipase; Phospholipase C beta - chemistry; Phospholipase C beta - metabolism; Phosphorylation; Protein Binding; Protein Conformation; Receptors, G-Protein-Coupled - metabolism; Signal Transduction

Harden et al examine C-beta signaling nodes with regard to the mechanism of activation and inactivation of Gq/phospholipase.