Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review
Individuals who carry an inherited mutation in the breast cancer 1 (BRCA1) and BRCA2 genes have a significant risk of developing breast and ovarian cancer over the course of their lifetime. As a result, there are important considerations for the clinician in the counseling, followup and management o...
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Published in | International Journal of Surgical Oncology Vol. 2011; no. 2011; pp. 91 - 101 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Cairo, Egypt
Hindawi Limiteds
01.01.2011
Hindawi Puplishing Corporation Hindawi Publishing Corporation Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Individuals who carry an inherited mutation in the breast cancer 1 (BRCA1) and BRCA2 genes have a significant risk of developing breast and ovarian cancer over the course of their lifetime. As a result, there are important considerations for the clinician in the counseling, followup and management of mutation carriers. This review outlines salient aspects in the approach to patients at high risk of developing breast and ovarian cancer, including criteria for genetic testing, screening guidelines, surgical prophylaxis, and chemoprevention. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Bernardo Garicochea |
ISSN: | 2090-1402 2090-1410 |
DOI: | 10.1155/2011/374012 |