Maribavir Pharmacokinetics and the Effects of Multiple-Dose Maribavir on Cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-Acetyltransferase-2, and Xanthine Oxidase Activities in Healthy Adults

• Published in: Antimicrobial Agents and Chemotherapy Vol. 50; no. 4; pp. 1130 - 1135
• Main Authors: Ma, Joseph D., Nafziger, Anne N., Villano, Stephen A., Gaedigk, Andrea, Bertino, Joseph S.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.04.2006
• Subjects: Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Antiviral Agents - pharmacology; Aryl Hydrocarbon Hydroxylases - metabolism; Arylamine N-Acetyltransferase - metabolism; Benzimidazoles; Benzimidazoles - pharmacokinetics; Benzimidazoles - pharmacology; Biological and medical sciences; Cytochrome P-450 CYP1A2 - metabolism; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 - metabolism; Cytochrome P-450 CYP3A - metabolism; Double-Blind Method; Drug Interactions; Humans; Medical sciences; Mixed Function Oxygenases - metabolism; Pharmacology. Drug treatments; Ribonucleosides; Ribonucleosides - pharmacokinetics; Ribonucleosides - pharmacology; Therapeutic Equivalency; Xanthine Oxidase - metabolism; Human; Acyltransferases; Enzyme; Transferases; Arylamine N-acetyltransferase; Biological activity; Multiple dose; Maribavir; Adult; Antiviral; Xanthine oxidase; Oxidoreductases; Pharmacokinetics

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