Maribavir Pharmacokinetics and the Effects of Multiple-Dose Maribavir on Cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-Acetyltransferase-2, and Xanthine Oxidase Activities in Healthy Adults

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Published inAntimicrobial Agents and Chemotherapy Vol. 50; no. 4; pp. 1130 - 1135
Main Authors Ma, Joseph D., Nafziger, Anne N., Villano, Stephen A., Gaedigk, Andrea, Bertino, Joseph S.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.04.2006
Subjects
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Antiviral Agents - pharmacology
Aryl Hydrocarbon Hydroxylases - metabolism
Arylamine N-Acetyltransferase - metabolism
Benzimidazoles
Benzimidazoles - pharmacokinetics
Benzimidazoles - pharmacology
Biological and medical sciences
Cytochrome P-450 CYP1A2 - metabolism
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2D6 - metabolism
Cytochrome P-450 CYP3A - metabolism
Double-Blind Method
Drug Interactions
Humans
Medical sciences
Mixed Function Oxygenases - metabolism
Pharmacology. Drug treatments
Ribonucleosides
Ribonucleosides - pharmacokinetics
Ribonucleosides - pharmacology
Therapeutic Equivalency
Xanthine Oxidase - metabolism
Human
Acyltransferases
Enzyme
Transferases
Arylamine N-acetyltransferase
Biological activity
Multiple dose
Maribavir
Adult
Antiviral
Xanthine oxidase
Oxidoreductases
Pharmacokinetics
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Present address: ORI Drug Development Center, Ordway Research Institute, Inc., 150 New Scotland Ave., Albany, NY 12208. Phone: (518) 641-6410. Fax: (518) 641-6304. E-mail: sbertino@ix.netcom.com.
Present address: Amgen Inc., Thousand Oaks, CA 91320.
Present address: ORI Drug Development Center, Ordway Research Institute, Inc., Albany, NY 12208.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.50.4.1130-1135.2006