Utilizing Recombinant Spider Silk Proteins To Develop a Synthetic Bruch’s Membrane for Modeling the Retinal Pigment Epithelium

• Published in: ACS biomaterials science & engineering Vol. 5; no. 8; pp. 4023 - 4036
• Main Authors: Harris, Thomas I, Paterson, Chase A, Farjood, Farhad, Wadsworth, Ian D, Caldwell, Lori, Lewis, Randolph V, Jones, Justin A, Vargis, Elizabeth
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.08.2019
• Subjects: films; Bruch’s membrane; scaffold; biomimetic; model; spider silk; RPE cells

Spider silks are intriguing biomaterials that have a high potential as innovative biomedical processes and devices. The intent of this study was to evaluate the capacity of recombinant spider silk proteins (rSSps) as a synthetic Bruch’s membrane. Nonporous silk membranes were prepared with comparabl...