Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. The main activity of exosomes is cellular communication. In cancer, exosomes play an important rolefrom two distinct perspectives, one related to carcinogenesis and the other as the...

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Published inACS biomaterials science & engineering Vol. 9; no. 2; pp. 577 - 594
Main Authors Kar, Rishav, Dhar, Rajib, Mukherjee, Sayantanee, Nag, Sagnik, Gorai, Sukhamoy, Mukerjee, Nobendu, Mukherjee, Dattatreya, Vatsa, Rishabh, Chandrakanth Jadhav, Mamtha, Ghosh, Arabinda, Devi, Arikketh, Krishnan, Anand, Thorat, Nanasaheb D.
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 13.02.2023
Subjects
Drug Delivery Systems - methods
Exosomes - metabolism
Extracellular Vesicles - metabolism
Humans
Neoplasms - diagnosis
Neoplasms - drug therapy
Phospholipids - metabolism
Phospholipids - therapeutic use
Precision Medicine
Review
cancer
drug delivery
cancer biomarker
drug loading methods
Eexosomes
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Summary:Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. The main activity of exosomes is cellular communication. In cancer, exosomes play an important rolefrom two distinct perspectives, one related to carcinogenesis and the other as theragnostic and drug delivery tools. The outer phospholipid membrane of Exosome improves drug targeting efficiency. . Some of the vital features of exosomes such as biocompatibility, low toxicity, and low immunogenicity make it a more exciting drug delivery system. Exosome-based drug delivery is a new innovative approach to cancer treatment. Exosome-associated biomarker analysis heralded a new era of cancer diagnostics in a more specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with cancer and exosome-related cancer biomarkers, drug loading methods, exosome-based biomolecule delivery, advances and limitations of exosome-based drug delivery, and exosome-based drug delivery in clinical settings studies. The exosome-based understanding of cancer will change the diagnostic and therapeutic approach in the future.
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ISSN:2373-9878
2373-9878
DOI:10.1021/acsbiomaterials.2c01329