Diagnostic accuracy of smear microscopy, mycobacterial culture, and GeneXpert MTB/RIF assay for diagnosis of subclinical tuberculosis: a retrospective multicenter study

Subclinical tuberculosis (TB) poses a major challenge to public health interventions, especially in the wake of the COVID-19 pandemic. However, a substantial proportion of individuals have absence or non-recognized symptoms, which put great pressure on clinical diagnosis. In this study, we conducted...

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Published inMicrobiology spectrum Vol. 13; no. 5; p. e0188824
Main Authors Shi, Jin, Yu, Yanhong, Li, Bo, Shang, Yuanyuan, Yao, Cong, Ren, Weicong, Li, Shanshan, Gao, Mengqiu, Pang, Yu
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 06.05.2025
Subjects
Adult
Aged
asymptomatic
China
diagnostic methods
Epidemiology
Female
Humans
Interferon-gamma Release Tests
Male
Microscopy - methods
Middle Aged
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
prevalence
Research Article
Retrospective Studies
Risk Factors
Sensitivity and Specificity
subclinical
tuberculosis
Tuberculosis - diagnosis
Tuberculosis - microbiology
Young Adult
China
prevalence
diagnostic methods
subclinical
asymptomatic
tuberculosis
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Summary:Subclinical tuberculosis (TB) poses a major challenge to public health interventions, especially in the wake of the COVID-19 pandemic. However, a substantial proportion of individuals have absence or non-recognized symptoms, which put great pressure on clinical diagnosis. In this study, we conducted a retrospective multicenter study to assess the performance of smear microscopy, mycobacterial culture, and GeneXpert MTB/RIF (Xpert) in diagnosis of subclinical TB. We also aimed to determine the proportion and risk factors of subclinical TB in China in order to accelerate progress towards global milestones and targets for the End TB Strategy.
Bibliography:ObjectType-Article-1
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The authors declare no conflict of interest.
Jin Shi, Yanhong Yu, Bo Li, and Yuanyuan Shang contributed equally to this article. The order of the co-first authors is determined based on their contributions in the crucial research aspects.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.01888-24