Improving the Sensitivity of FESTA Methods for the Analysis of Fluorinated Mixtures

The analysis of complex mixtures is an important but often intractable problem. When species contain sparse fluorine atoms, NMR spectra of fluorine-containing spin systems can be efficiently extracted from an intact mixture using the recently proposed FESTA (Fluorine-Edited Selective TOCSY Acquisiti...

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Bibliographic Details
Published inAnalytical chemistry (Washington) Vol. 92; no. 2; pp. 2224 - 2228
Main Authors Barbosa, Thaís M, Castañar, Laura, Moutzouri, Pinelopi, Nilsson, Mathias, Morris, Gareth A, Rittner, Roberto, Tormena, Claudio F
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 21.01.2020
Subjects
Analytical chemistry
Chemistry
Fluorine
NMR
Nuclear magnetic resonance
Sensitivity analysis
Spectral sensitivity
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Summary:The analysis of complex mixtures is an important but often intractable problem. When species contain sparse fluorine atoms, NMR spectra of fluorine-containing spin systems can be efficiently extracted from an intact mixture using the recently proposed FESTA (Fluorine-Edited Selective TOCSY Acquisition) methodology. Here an alternative approach to the existing selective reverse INEPT FESTA (SRI-FESTA) experiment is described, based on the use of a modulated spin echo for the initial excitation. MODO-FESTA (modulated echo FESTA) is simpler and has a significant sensitivity advantage over SRI-FESTA. Comparisons are presented of the relative sensitivity and spectral purity of the two types of methods.
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content type line 23
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.9b04924