Obese individuals exhibit distinct temporal gene expression dynamics in response to influenza vaccination

This study yields insights into how co-morbidities, such as obesity, impact the immune response to the seasonal influenza vaccine. By analyzing blood samples collected days and weeks after the vaccination of a cohort of subjects, we can examine changes in gene expression over time and how those chan...

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Bibliographic Details
Published inMicrobiology spectrum Vol. 13; no. 8; p. e0335424
Main Authors Hockman, Megan, Matthews, Julia, Carlock, Michael A., Ross, Ted M., Gresham, David, Ghedin, Elodie
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 23.06.2025
Subjects
Adaptive Immunity
Adult
Aged
Female
gene expression
Gene Expression Profiling
Genomics and Proteomics
Humans
influenza vaccines
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - immunology
Influenza, Human - prevention & control
Male
Middle Aged
obesity
Obesity - genetics
Obesity - immunology
Research Article
Transcriptome
Vaccination
Young Adult
influenza vaccines
gene expression
obesity
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Summary:This study yields insights into how co-morbidities, such as obesity, impact the immune response to the seasonal influenza vaccine. By analyzing blood samples collected days and weeks after the vaccination of a cohort of subjects, we can examine changes in gene expression over time and how those changes are similar or different depending on risk factors. This provides clues into potential molecular mechanisms behind an effective immune response to vaccination.
Bibliography:ObjectType-Article-1
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The authors declare no conflict of interest.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.03354-24