A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus

• Published in: Journal of natural products (Washington, D.C.) Vol. 73; no. 2; pp. 255 - 257
• Main Authors: Inman, Wayne D, Bray, Walter M, Gassner, Nadine C, Lokey, R. Scott, Tenney, Karen, Shen, Young Yongchun, TenDyke, Karen, Suh, Ted, Crews, Phillip
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 26.02.2010; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Animals; Biological and medical sciences; Carbolines - chemistry; Carbolines - isolation & purification; Carbolines - pharmacology; Chemistry, Medicinal; Drug Screening Assays, Antitumor; Female; General pharmacology; HeLa Cells; HT29 Cells; Humans; Life Sciences & Biomedicine; Male; Marine Biology; Medical sciences; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Papua New Guinea; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Porifera - chemistry; Science & Technology; Stereoisomerism; Papua New Guinea; Melanesia; Oceania; ANTINEOPLASTIC AGENTS; ERECTA; INHIBITOR; PUUPEHENONE; Antineoplastic agent; Human; Imidazole derivatives; Nitrogen heterocycle; Histiocytic lymphoma; Pharmacognosy; Animal origin; Cytotoxicity; non-small cell lung carcinoma; Tricyclic compound; In vitro; Biological activity; Marine environment; Alkaloid; Cell line; Carboxylic acid; Porifera; Phenols; Isolation; Mammary gland; Invertebrata; Tumor cell; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np9005426

A new 1-imidazoyl-3-carboxy-6-hydroxy-β-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including 1H−15N HMBC NMR experiments, which provided complementary 15N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.