Solubility of Anti-Inflammatory Drugs in Supercritical Carbon Dioxide
Supercritical fluid extraction is a potential technique for the purification of pharmaceutical products containing residual solvents. The solubilities of the drugs in supercritical carbon dioxide are being measured as part of a program in which the potential applications of this technology are being...
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| Published in | Journal of chemical and engineering data Vol. 41; no. 5; pp. 1083 - 1086 |
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| Main Authors | , , , , , |
| Format | Journal Article Conference Proceeding |
| Language | English |
| Published |
Washington, DC
American Chemical Society
1996
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| Subjects | |
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| Abstract | Supercritical fluid extraction is a potential technique for the purification of pharmaceutical products containing residual solvents. The solubilities of the drugs in supercritical carbon dioxide are being measured as part of a program in which the potential applications of this technology are being investigated. The solubilities of three inhibitors of inflammatory activity, Ketoprofen, Piroxicam, and Nimesulide, in supercritical CO2, measured using a dynamic saturation technique, are reported at pressures between 100 bar and 220 bar and at two temperatures: 312.5 K and 331.5 K. These chemicals have relatively high solubilities with values ranging from 4 × 10-6 to 15 × 10-4 mole fraction. The solubilities exhibit a clear dependence on the solvent density, and this has been used to provide a simple and precise correlation of the data. |
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| AbstractList | Supercritical fluid extraction is a potential technique for the purification of pharmaceutical products containing residual solvents. The solubilities of the drugs in supercritical carbon dioxide are being measured as part of a program in which the potential applications of this technology are being investigated. The solubilities of three inhibitors of inflammatory activity, Ketoprofen, Piroxicam, and Nimesulide, in supercritical CO2, measured using a dynamic saturation technique, are reported at pressures between 100 bar and 220 bar and at two temperatures: 312.5 K and 331.5 K. These chemicals have relatively high solubilities with values ranging from 4 × 10-6 to 15 × 10-4 mole fraction. The solubilities exhibit a clear dependence on the solvent density, and this has been used to provide a simple and precise correlation of the data. Supercritical fluid extraction is a potential technique for the purification of pharmaceutical products containing residual solvents. The solubilities of the drugs in supercritical carbon dioxide are being measured as part of a program in which the potential applications of this technology are being investigated. The solubilities of three inhibitors of inflammatory activity, Ketoprofen, Piroxicam, and Nimesulide, in supercritical CO sub(2), measured using a dynamic saturation technique, are reported at pressures between 100 bar and 220 bar and at two temperatures: 312.5 K and 331.5 K. These chemicals have relatively high solubilities with values ranging from 4x10 super(-6) to 15x10 super(-4) mole fraction. The solubilities exhibit a clear dependence on the solvent density, and this has been used to provide a simple and precise correlation of the data. |
| Author | Kikic, Ireneo Cortesi, Angelo Macnaughton, Stuart J Colombo, Italo Foster, Neil R Alessi, Paolo |
| Author_xml | – sequence: 1 givenname: Stuart J surname: Macnaughton fullname: Macnaughton, Stuart J – sequence: 2 givenname: Ireneo surname: Kikic fullname: Kikic, Ireneo – sequence: 3 givenname: Neil R surname: Foster fullname: Foster, Neil R – sequence: 4 givenname: Paolo surname: Alessi fullname: Alessi, Paolo – sequence: 5 givenname: Angelo surname: Cortesi fullname: Cortesi, Angelo – sequence: 6 givenname: Italo surname: Colombo fullname: Colombo, Italo |
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| Cites_doi | 10.1002/anie.197807311 10.1021/je00019a011 10.1021/ie00051a020 10.1021/ie00059a019 10.1021/ie00056a044 10.1016/0896-8446(88)90005-8 10.1021/ie00035a027 |
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| Keywords | Supercritical solvent Purification Physicochemical properties Antiinflammatory agent Solubility |
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| References | Foster N. R. (atypb1/atypb2) 1991; 30 Macnaughton S. J. (atypb9/atypb10) 1995; 40 Mihalic M. (atypb11/atypb12) 1986; 15 Stahl E. (atypb15/atypb16) 1978; 17 Gurdial G. S. (atypb3/atypb4) 1991; 30 Reverchon E. (atypb13/atypb14) 1994; 6 Macnaughton S. J. (atypb7/atypb8) 1994; 33 Kumar S. K. (atypb5/atypb6) 1988; 1 Yun S. L. (atypb17/atypb18) 1991; 30 |
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| Title | Solubility of Anti-Inflammatory Drugs in Supercritical Carbon Dioxide |
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