Solubility of Anti-Inflammatory Drugs in Supercritical Carbon Dioxide

• Published in: Journal of chemical and engineering data Vol. 41; no. 5; pp. 1083 - 1086
• Main Authors: Macnaughton, Stuart J, Kikic, Ireneo, Foster, Neil R, Alessi, Paolo, Cortesi, Angelo, Colombo, Italo
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Washington, DC American Chemical Society 1996
• Subjects: Analysis; Biological and medical sciences; General pharmacology; Medical sciences; Pharmacology. Drug treatments; Supercritical solvent; Purification; Physicochemical properties; Antiinflammatory agent; Solubility
• ISSN: 0021-9568; 1520-5134
• DOI: 10.1021/je960103q

Supercritical fluid extraction is a potential technique for the purification of pharmaceutical products containing residual solvents. The solubilities of the drugs in supercritical carbon dioxide are being measured as part of a program in which the potential applications of this technology are being investigated. The solubilities of three inhibitors of inflammatory activity, Ketoprofen, Piroxicam, and Nimesulide, in supercritical CO2, measured using a dynamic saturation technique, are reported at pressures between 100 bar and 220 bar and at two temperatures:  312.5 K and 331.5 K. These chemicals have relatively high solubilities with values ranging from 4 × 10-6 to 15 × 10-4 mole fraction. The solubilities exhibit a clear dependence on the solvent density, and this has been used to provide a simple and precise correlation of the data.