Immunological mechanisms of tuberculosis susceptibility in TB-infected individuals with type 2 diabetes mellitus: insights from mycobacterial growth inhibition assay and cytokine analysis

This study is important because it sheds light on the impaired immune response in individuals with type 2 diabetes mellitus (T2DM) who are infected with Mycobacterium tuberculosis (M.tb), offering critical insights into why they are at higher risk of developing active tuberculosis (TB). By demonstra...

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Published inMicrobiology spectrum Vol. 13; no. 1; p. e0144524
Main Authors Dasan, Bindu, Rajamanickam, Anuradha, Pandiarajan, Arul Nancy, Shanmugam, Sivakumar, Nott, Sujatha, Babu, Subash
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 07.01.2025
Subjects
Adult
Aged
Clinical Microbiology
cytokines
Cytokines - immunology
Cytokines - metabolism
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - immunology
Diabetes Mellitus, Type 2 - microbiology
Disease Susceptibility - immunology
Female
Humans
Male
Middle Aged
mycobacterial growth inhibition assay
Mycobacterium tuberculosis - growth & development
Mycobacterium tuberculosis - immunology
Research Article
TB infection
Tuberculosis - immunology
Tuberculosis - microbiology
type 2 diabetes mellitus
mycobacterial growth inhibition assay
type 2 diabetes mellitus
cytokines
TB infection
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Summary:This study is important because it sheds light on the impaired immune response in individuals with type 2 diabetes mellitus (T2DM) who are infected with Mycobacterium tuberculosis (M.tb), offering critical insights into why they are at higher risk of developing active tuberculosis (TB). By demonstrating that T2DM individuals exhibit a weakened ability to control M.tb growth and a compromised cytokine profile, the research underscores the need for better diagnostic tools, such as the mycobacterial growth inhibition assay (MGIA), to identify those at greater risk of progression to active TB. The findings also highlight the importance of integrated care strategies for managing both T2DM and TB, particularly in TB-endemic regions, and point to the need for further research to develop more effective interventions tailored to this vulnerable population.
Bibliography:ObjectType-Article-1
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The authors declare no conflict of interest.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.01445-24