Flagellum-deficient Pseudomonas aeruginosa is more virulent than non-motile but flagellated mutants in a cystic fibrosis mouse model

Pseudomonas aeruginosa , a major respiratory pathogen in cystic fibrosis, is known to lose its flagellum during the course of infection in the airways. Here, we show that the loss of flagellum leads to a more enhanced virulence in Cftr-deficient cystic fibrosis mice than in control animals. Loss of...

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Published inMicrobiology spectrum Vol. 12; no. 10; p. e0132524
Main Authors Moustafa, Dina A., Fantone, Kayla M., Tucker, Samantha L., McCarty, Nael A., Stecenko, Arlene A., Goldberg, Joanna B., Rada, Balázs
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 03.10.2024
Subjects
Bacteriology
cystic fibrosis
flagellum
infection
inflammation
motility
Pseudomonas aeruginosa
Research Article
infection
flagellum
inflammation
cystic fibrosis
neutrophil elastase
Pseudomonas aeruginosa
motility
neutrophil
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Summary:Pseudomonas aeruginosa , a major respiratory pathogen in cystic fibrosis, is known to lose its flagellum during the course of infection in the airways. Here, we show that the loss of flagellum leads to a more enhanced virulence in Cftr-deficient cystic fibrosis mice than in control animals. Loss of flagellum expression, rather than the loss of flagellar swimming motility, represents the main driver behind this increased virulence suggesting that this appendage plays a specific role in P. aeruginosa virulence in cystic fibrosis airways.
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The authors declare no conflict of interest.
Joanna B. Goldberg and Balázs Rada contributed equally to this article.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.01325-24