Occidiofungin inhibition of Candida biofilm formation on silicone elastomer surface

are opportunistic fungal pathogens with medical relevance given their association with superficial to life-threatening infections. An important component of virulence is the ability to form a biofilm. These structures are highly resistant to antifungal therapies and are often the cause of treatment...

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Published inMicrobiology spectrum Vol. 11; no. 6; p. e0246023
Main Authors Kumpakha, Rabina, Gordon, Donna M
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 12.12.2023
Subjects
antifungal agents
Antimicrobial Chemotherapy
biofilms
Candida albicans
Candida tropicalis
Research Article
Candida albicans
Candida tropicalis
antifungal agents
biofilms
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Summary:are opportunistic fungal pathogens with medical relevance given their association with superficial to life-threatening infections. An important component of virulence is the ability to form a biofilm. These structures are highly resistant to antifungal therapies and are often the cause of treatment failure. In this work, we evaluated the efficacy of the antifungal compound, occidiofungin, against biofilms developed on a silicone surface. We demonstrate that occidiofungin eliminated cells at all stages of biofilm formation in a dose-dependent manner. Consistent with our understanding of occidiofungin bioactivity, we noted alterations to actin organization and cell morphology following antifungal exposure. Given the challenges associated with the treatment of biofilm-associated infections, occidiofungin exhibits potential as a therapeutic antifungal agent in the future.
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The authors declare no conflict of interest.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.02460-23