Characterization of Pseudomonas aeruginosa from subjects with diffuse panbronchiolitis

Diffuse panbronchiolitis (DPB), a chronic lung disease characterized by persistent P. aeruginosa infection, serves as an informative comparator to more common chronic lung diseases, such as cystic fibrosis (CF). This study aimed to better address the interplay between P. aeruginosa and chronically c...

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Published inMicrobiology spectrum Vol. 12; no. 11; p. e0053024
Main Authors Met, Charles M., Hofstaedter, Casey E., O'Keefe, Ian P., Yang, Hyojik, Moustafa, Dina A., Sherman, Matthew E., Doi, Yohei, Rasko, David A., Sweet, Charles R., Goldberg, Joanna B., Ernst, Robert K.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 05.11.2024
Subjects
adaptation
Bacteriology
diffuse panbronchiolitis
LPS
Pseudomonas aeruginosa
Research Article
Pseudomonas aeruginosa
adaptation
diffuse panbronchiolitis
LPS
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Summary:Diffuse panbronchiolitis (DPB), a chronic lung disease characterized by persistent P. aeruginosa infection, serves as an informative comparator to more common chronic lung diseases, such as cystic fibrosis (CF). This study aimed to better address the interplay between P. aeruginosa and chronically compromised airway environments through the examination of DPB P. aeruginosa strains, as existing literature regarding DPB is limited to case reports, case series, and clinical treatment guidelines. The evaluation of these features in the context of DPB, in tandem with prevailing knowledge of P. aeruginosa strains collected from more common chronic lung diseases (e.g., CF), can aid in the development of more effective strategies to combat respiratory P. aeruginosa infections in patients with chronic lung diseases.
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Charles M. Met and Casey E. Hofstaedter contributed equally to this article. Author order was determined by agreement of authors and based on the order that they started the original project.
The authors declare no conflict of interest.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.00530-24