Closing the Loop: Developing an Integrated Design, Make, and Test Platform for Discovery

• Published in: ACS medicinal chemistry letters Vol. 10; no. 6; pp. 848 - 856
• Main Author: Parry, David M
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 13.06.2019
• Subjects: Innovations; Integration; Design Make and Test; Flow Synthesis; ABL1 Kinase; Automated Discovery

The relatively slow cycle time within medicinal chemistry from synthesis to assay is constantly being challenged to help improve the efficiency of the discovery process. While both synthesis and assay have been automated to varying degrees, there has, until recently, been limited focus on the comple...