Closing the Loop: Developing an Integrated Design, Make, and Test Platform for Discovery

The relatively slow cycle time within medicinal chemistry from synthesis to assay is constantly being challenged to help improve the efficiency of the discovery process. While both synthesis and assay have been automated to varying degrees, there has, until recently, been limited focus on the comple...

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Bibliographic Details
Published inACS medicinal chemistry letters Vol. 10; no. 6; pp. 848 - 856
Main Author Parry, David M
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 13.06.2019
Subjects
Innovations
Integration
Design Make and Test
Flow Synthesis
ABL1 Kinase
Automated Discovery
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Summary:The relatively slow cycle time within medicinal chemistry from synthesis to assay is constantly being challenged to help improve the efficiency of the discovery process. While both synthesis and assay have been automated to varying degrees, there has, until recently, been limited focus on the complete design, make, and test process. This Innovations article outlines the development of Cyclofluidic from inception through to the commercialization of a fully integrated closed loop design, synthesis, and screen platform.
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ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.9b00095