The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review

Exposure to polychlorinated biphenyls (PCBs) is implicated in adverse neurotoxic outcomes. However, the impact of PCBs on the adolescent nervous system has received inadequate attention. We conducted a comprehensive review to identify studies of neurotoxic outcomes following PCB exposure during the...

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Bibliographic Details
Published inChemical research in toxicology Vol. 34; no. 9; pp. 1948 - 1952
Main Authors Bullert, Amanda J, Doorn, Jonathan A, Stevens, Hanna E, Lehmler, Hans-Joachim
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 20.09.2021
Subjects
Adolescent
Animals
Humans
Nervous System - drug effects
Polychlorinated Biphenyls - toxicity
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Summary:Exposure to polychlorinated biphenyls (PCBs) is implicated in adverse neurotoxic outcomes. However, the impact of PCBs on the adolescent nervous system has received inadequate attention. We conducted a comprehensive review to identify studies of neurotoxic outcomes following PCB exposure during the adolescent period in rodents. Only four papers were found to meet all inclusion criteria. PCB exposure in adolescent rats caused disruptions in the main functions of the prefrontal cortex, resulting in cognitive deficits. This comprehensive review demonstrates that more research is needed to characterize how PCB exposure adversely affects the adolescent nervous system.
ISSN:0893-228X
1520-5010
DOI:10.1021/acs.chemrestox.1c00226