Pulmonary Alveolar Microlithiasis A Case Report
Pulmonary alveolar microlithiasis (PAM) is a rare disease caused by a mutation in the SLC34A2 gene encoding the type IIb sodium phosphate cotransporter in alveolar type II cells. This results in the formation and accumulation of calcium phosphates crystals in the alveoli. Early in the disease, most...
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Published in | Oman medical journal Vol. 35; no. 2; pp. 1 - 4 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Muscat - Oman
Oman Medical Specialty Board
01.03.2020
OMJ |
Subjects | |
Online Access | Get full text |
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Summary: | Pulmonary alveolar microlithiasis (PAM) is a rare disease caused by a mutation in the SLC34A2 gene encoding the type IIb sodium phosphate cotransporter in alveolar type II cells. This results in the formation and accumulation of calcium phosphates crystals in the alveoli. Early in the disease, most patients are asymptomatic or might experience mild symptoms. However, in some patients, PAM can progress resulting in pulmonary fibrosis, cor pulmonale, and respiratory failure. We report the case of a 33-year-old Omani male who was referred to our institute with a history of fever and shortness of breath. A chest radiograph revealed bilateral dense consolidation. Chest computed tomography showed bilateral dense interlobular thickening and extensive consolidations with a lower lung predominance. Our findings were highly suggestive of PAM. The diagnosis was confirmed by bronchoalveolar lavage. |
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Bibliography: | OMJ.jpg Oman Medical Journal, Vol. 35, No. 2, Mar 2020: [1]-[4] |
ISSN: | 1999-768X 2070-5204 |
DOI: | 10.5001/omj.2020.33 |