Systematic Identification of Protein Phosphorylation-Mediated Interactions

• Published in: Journal of proteome research Vol. 20; no. 2; pp. 1359 - 1370
• Main Authors: Floyd, Brendan M, Drew, Kevin, Marcotte, Edward M
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 05.02.2021
• Subjects: Amino Acid Sequence; Chromatography, Gel; Mass Spectrometry; Phosphorylation; Proteins; protein interactions; protein phosphorylation; protein complexes; size-exclusion chromatography; high-throughput

Protein phosphorylation is a key regulatory mechanism involved in nearly every eukaryotic cellular process. Increasingly sensitive mass spectrometry approaches have identified hundreds of thousands of phosphorylation sites, but the functions of a vast majority of these sites remain unknown, with few...