Validation and Application of an HPLC-DAD Method for Routine Therapeutic Drug Monitoring of Ceftobiprole

Ceftobiprole is a fifth-generation cephalosporin approved for the treatment of pneumonia, with a broad antibacterial spectrum, including potent activity against methicillin-resistant As for the other cephalosporins, high pharmacokinetic variability and concentration-dependent neurotoxicity are expec...

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Published inAntimicrobial agents and chemotherapy Vol. 63; no. 7
Main Authors Lima, Benjamin, Bodeau, Sandra, Quinton, Marie-Charlotte, Leven, Cyril, Lemaire-Hurtel, Anne-Sophie, Bennis, Youssef
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.07.2019
Subjects
Aged
Anti-Bacterial Agents
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - blood
Calibration
Cephalosporins
Cephalosporins - adverse effects
Cephalosporins - blood
Chromatography, High Pressure Liquid
Chromatography, High Pressure Liquid - methods
Drug Monitoring
Drug Monitoring - methods
Female
Humans
Life Sciences
Male
Pharmacology
Seizures - chemically induced
neurotoxicity
pneumonia
cephalosporin
therapeutic drug monitoring
MRSA
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Summary:Ceftobiprole is a fifth-generation cephalosporin approved for the treatment of pneumonia, with a broad antibacterial spectrum, including potent activity against methicillin-resistant As for the other cephalosporins, high pharmacokinetic variability and concentration-dependent neurotoxicity are expected. We describe here the first simple and rapid analytical method intended for ceftobiprole serum concentration monitoring. We report the data of 5 patients treated with ceftobiprole, among who 2 developed reversible neurological disorders with high ceftobiprole serum concentration.
Bibliography:PMCID: PMC6591631
Citation Lima B, Bodeau S, Quinton M-C, Leven C, Lemaire-Hurtel A-S, Bennis Y. 2019. Validation and application of an HPLC-DAD method for routine therapeutic drug monitoring of ceftobiprole. Antimicrob Agents Chemother 63:e00515-19. https://doi.org/10.1128/AAC.00515-19.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00515-19