Hydrogels for Therapeutic Delivery: Current Developments and Future Directions

Hydrogels are attractive materials for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. Recent advances in organic and polymer chemistry, bioengineering and nanotechnology have resulted in several new developments in...

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Bibliographic Details
Published inBiomacromolecules Vol. 18; no. 2; pp. 316 - 330
Main Authors Buwalda, Sytze J, Vermonden, Tina, Hennink, Wim E
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 13.02.2017
Subjects
Biocompatible Materials
bioengineering
crosslinking
Drug Carriers - chemistry
Drug Delivery Systems
Humans
hydrogels
Hydrogels - administration & dosage
Hydrogels - chemistry
nanoparticles
polymers
Polymers - administration & dosage
Polymers - chemistry
therapeutics
Tissue Engineering
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Summary:Hydrogels are attractive materials for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. Recent advances in organic and polymer chemistry, bioengineering and nanotechnology have resulted in several new developments in the field of hydrogels for therapeutic delivery. In this Perspective, we present our view on the state-of-the-art in the field, thereby focusing on a number of exciting topics, including bioorthogonal cross-linking methods, multicomponent hydrogels, stimuli-responsive hydrogels, nanogels, and the release of therapeutics from 3D printed hydrogels. We also describe the challenges that should be overcome to facilitate translation from academia to the clinic and last, we share our ideas about the future of this rapidly evolving area of research.
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ISSN:1525-7797
1526-4602
1526-4602
DOI:10.1021/acs.biomac.6b01604