The corticotropin-releasing hormone stimulation test in chronic schizophrenia

During a drug-free period a group of schizophrenic subjects (N = 9) showed normal mean basal plasma ACTH and cortisol levels in association with normal plasma ACTH and cortisol responses to an infusion of corticotropin-releasing hormone (CRH). Administration of fluphenazine had no effect on basal AC...

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Bibliographic Details
Published inThe American journal of psychiatry Vol. 143; no. 11; p. 1393
Main Authors Roy, A, Pickar, D, Doran, A, Wolkowitz, O, Gallucci, W, Chrousos, G, Gold, P
Format Journal Article
LanguageEnglish
Published United States 01.11.1986
Subjects
Adrenocorticotropic Hormone - blood
Adult
Chronic Disease
Corticotropin-Releasing Hormone - pharmacology
Depressive Disorder - blood
Depressive Disorder - diagnosis
Depressive Disorder - physiopathology
Female
Humans
Hydrocortisone - blood
Hypothalamo-Hypophyseal System - physiopathology
Male
Middle Aged
Pituitary-Adrenal System - physiopathology
Schizophrenia - blood
Schizophrenia - diagnosis
Schizophrenia - physiopathology
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Summary:During a drug-free period a group of schizophrenic subjects (N = 9) showed normal mean basal plasma ACTH and cortisol levels in association with normal plasma ACTH and cortisol responses to an infusion of corticotropin-releasing hormone (CRH). Administration of fluphenazine had no effect on basal ACTH and cortisol levels or their responses to CRH (N = 8). These data differ from those previously reported in depressed patients, who showed elevated basal cortisol values in association with a blunted ACTH response to CRH, and add to a growing body of literature which suggests that hypothalamic-pituitary-adrenal regulation is less disturbed in schizophrenia than in depression.
ISSN:0002-953X
DOI:10.1176/ajp.143.11.1393