VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection

We studied the efficacy of the investigational drug VT-1161 against mucormycosis. VT-1161 had more potent in vitro activity against Rhizopus arrhizus var. arrhizus than against R. arrhizus var. delemar. VT-1161 treatment demonstrated dose-dependent plasma drug levels with prolonged survival time and...

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Published inAntimicrobial agents and chemotherapy Vol. 59; no. 12; pp. 7815 - 7817
Main Authors Gebremariam, Teclegiorgis, Wiederhold, Nathan P, Fothergill, Annette W, Garvey, Edward P, Hoekstra, William J, Schotzinger, Robert J, Patterson, Thomas F, Filler, Scott G, Ibrahim, Ashraf S
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.12.2015
Subjects
Amphotericin B - pharmacology
Animals
Antifungal Agents
Antifungal Agents - blood
Antifungal Agents - pharmacokinetics
Antifungal Agents - pharmacology
Experimental Therapeutics
Immunocompromised Host
Male
Mice
Mice, Inbred ICR
Microbial Sensitivity Tests
Mucormycosis
Mucormycosis - drug therapy
Mucormycosis - immunology
Mucormycosis - microbiology
Mucormycosis - mortality
Pyridines
Pyridines - blood
Pyridines - pharmacokinetics
Pyridines - pharmacology
Rhizopus
Rhizopus - drug effects
Rhizopus - growth & development
Rhizopus arrhizus
Species Specificity
Survival Analysis
Tetrazoles
Tetrazoles - blood
Tetrazoles - pharmacokinetics
Tetrazoles - pharmacology
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Summary:We studied the efficacy of the investigational drug VT-1161 against mucormycosis. VT-1161 had more potent in vitro activity against Rhizopus arrhizus var. arrhizus than against R. arrhizus var. delemar. VT-1161 treatment demonstrated dose-dependent plasma drug levels with prolonged survival time and lowered tissue fungal burden in immunosuppressed mice infected with R. arrhizus var. arrhizus and was as effective as high-dose liposomal amphotericin B treatment. These results support further development of VT-1161 against mucormycosis.
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Citation Gebremariam T, Wiederhold NP, Fothergill AW, Garvey EP, Hoekstra WJ, Schotzinger RJ, Patterson TF, Filler SG, Ibrahim AS. 2015. VT-1161 protects immunosuppressed mice from Rhizopus arrhizus var. arrhizus infection. Antimicrob Agents Chemother 59:7815–7817. doi:10.1128/AAC.01437-15.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01437-15