Synthetic Random Copolymers as a Molecular Platform To Mimic Host-Defense Antimicrobial Peptides

Synthetic polymers have been used as a molecular platform to develop host-defense antimicrobial peptide (AMP) mimetics which are effective in killing drug-resistant bacteria. In this topical review, we will discuss the AMP-mimetic design and chemical optimization strategies as well as the biological...

Full description

Saved in:
Bibliographic Details
Published inBioconjugate chemistry Vol. 28; no. 5; pp. 1340 - 1350
Main Authors Takahashi, Haruko, Caputo, Gregory A, Vemparala, Satyavani, Kuroda, Kenichi
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 17.05.2017
Subjects
Anti-Infective Agents - pharmacology
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobial Cationic Peptides - pharmacology
Antimicrobial peptides
Bacteria
Bacteria - drug effects
Biocompatibility
Biomimetics
Chains (polymeric)
Chemical synthesis
Copolymers
Design optimization
Drug resistance
Hydrophobicity
Mimicry
Mode of action
Molecules
Peptides
Physicochemical properties
Polymers
Polymers - chemical synthesis
Polymers - pharmacology
Topical Review
Online AccessGet full text

Cover

More Information
Summary:Synthetic polymers have been used as a molecular platform to develop host-defense antimicrobial peptide (AMP) mimetics which are effective in killing drug-resistant bacteria. In this topical review, we will discuss the AMP-mimetic design and chemical optimization strategies as well as the biological and biophysical implications of AMP mimicry by synthetic polymers. Traditionally, synthetic polymers have been used as a chemical means to replicate the chemical functionalities and physicochemical properties of AMPs (e.g., cationic charge, hydrophobicity) to recapitulate their mode of action. However, we propose a new perception that AMP-mimetic polymers are an inherently bioactive platform as whole molecules, which mimic more than the side chain functionalities of AMPs. The tunable nature and chemical simplicity of synthetic random polymers facilitate the development of potent, cost-effective, broad-spectrum antimicrobials. The polymer-based approach offers the potential for many antimicrobial applications to be used directly in solution or attached to surfaces to fight against drug-resistant bacteria.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.7b00114