In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa

• Published in: Antimicrobial agents and chemotherapy Vol. 59; no. 12; pp. 7915 - 7918
• Main Authors: Pires, João, Siriwardena, Thissa N, Stach, Michaela, Tinguely, Regula, Kasraian, Sara, Luzzaro, Francesco, Leib, Stephen L, Darbre, Tamis, Reymond, Jean-Louis, Endimiani, Andrea
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.12.2015
• Subjects: Acinetobacter baumannii; Acinetobacter baumannii - drug effects; Acinetobacter baumannii - enzymology; Acinetobacter baumannii - genetics; Anti-Bacterial Agents; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; Antimicrobial Cationic Peptides; Antimicrobial Cationic Peptides - chemical synthesis; Antimicrobial Cationic Peptides - pharmacology; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; beta-Lactamases - genetics; beta-Lactamases - metabolism; beta-Lactams - pharmacology; Dendrimers; Dendrimers - chemical synthesis; Dendrimers - pharmacology; Drug Resistance, Multiple, Bacterial - drug effects; Drug Resistance, Multiple, Bacterial - genetics; Experimental Therapeutics; Gene Expression; Isoenzymes - genetics; Isoenzymes - metabolism; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - enzymology; Pseudomonas aeruginosa - genetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01853-15

The in vitro activity of the novel antimicrobial peptide dendrimer G3KL was evaluated against 32 Acinetobacter baumannii (including 10 OXA-23, 7 OXA-24, and 11 OXA-58 carbapenemase producers) and 35 Pseudomonas aeruginosa (including 18 VIM and 3 IMP carbapenemase producers) strains and compared to the activities of standard antibiotics. Overall, both species collections showed MIC50/90 values of 8/8 μg/ml and minimum bactericidal concentrations at which 50% or 90% of strains tested are killed (MBC50/90) of 8/8 μg/ml. G3KL is a promising molecule with antibacterial activity against multidrug-resistant and extensively drug-resistant A. baumannii and P. aeruginosa isolates.