Flexible Glass-Based Hybrid Nanofluidic Device to Enable the Active Regulation of Single-Molecule Flows

Single-molecule studies offer deep insights into the essence of chemistry, biology, and materials science. Despite significant advances in single-molecule experiments, the precise regulation of the flow of single small molecules remains a formidable challenge. Herein, we present a flexible glass-bas...

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Bibliographic Details
Published inNano letters Vol. 23; no. 6; pp. 2210 - 2218
Main Authors Kawagishi, Hiroto, Funano, Shun-ichi, Tanaka, Yo, Xu, Yan
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 22.03.2023
Subjects
Letter
detection
dynamics
single molecules
nanoconfinement effects
nanofluidic channels
valves
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Summary:Single-molecule studies offer deep insights into the essence of chemistry, biology, and materials science. Despite significant advances in single-molecule experiments, the precise regulation of the flow of single small molecules remains a formidable challenge. Herein, we present a flexible glass-based hybrid nanofluidic device that can precisely block, open, and direct the flow of single small molecules in nanochannels. Additionally, this approach allows for real-time tracking of regulated single small molecules in nanofluidic conditions. Therefore, the dynamic behaviors of single small molecules confined in different nanofluidic conditions with varied spatial restrictions are clarified. Our device and approach provide a nanofluidic platform and mechanism that enable single-molecule studies and applications in actively regulated fluidic conditions, thus opening avenues for understanding the original behavior of individual molecules in their natural forms and the development of single-molecule regulated chemical and biological processes in the future.
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ISSN:1530-6984
1530-6992
DOI:10.1021/acs.nanolett.2c04807