Gold-Catalyzed Synthesis of Small Rings

Three- and four-membered rings, widespread motifs in nature and medicinal chemistry, have fascinated chemists ever since their discovery. However, due to energetic considerations, small rings are often difficult to assemble. In this regard, homogeneous gold catalysis has emerged as a powerful tool t...

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Bibliographic Details
Published inChemical reviews Vol. 121; no. 14; pp. 8613 - 8684
Main Authors Mato, Mauro, Franchino, Allegra, Garcı́a-Morales, Cristina, Echavarren, Antonio M
Format Journal Article
LanguageEnglish
Published Easton American Chemical Society 28.07.2021
Subjects
Catalysis
Chemical synthesis
Chemists
Gold
Organic compounds
Review
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Summary:Three- and four-membered rings, widespread motifs in nature and medicinal chemistry, have fascinated chemists ever since their discovery. However, due to energetic considerations, small rings are often difficult to assemble. In this regard, homogeneous gold catalysis has emerged as a powerful tool to construct these highly strained carbocycles. This review aims to provide a comprehensive summary of all the major advances and discoveries made in the gold-catalyzed synthesis of cyclopropanes, cyclopropenes, cyclobutanes, cyclobutenes, and their corresponding heterocyclic or heterosubstituted analogs.
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ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.0c00697