Plasmonic Microneedle Arrays for in Situ Sensing with Surface-Enhanced Raman Spectroscopy (SERS)

Surface-enhanced Raman spectroscopy (SERS) is a sensitive, chemically specific, and short-time response probing method with significant potential in biomedical sensing. This paper reports the integration of SERS with microneedle arrays as a minimally invasive platform for chemical sensing, with a pa...

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Bibliographic Details
Published inNano letters Vol. 19; no. 10; pp. 6862 - 6868
Main Authors Park, Ji Eun, Yonet-Tanyeri, Nihan, Vander Ende, Emma, Henry, Anne-Isabelle, Perez White, Bethany E, Mrksich, Milan, Van Duyne, Richard P
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 09.10.2019
Subjects
Plasmonic microneedle arrays
agar gel skin phantom
pH in situ sensing
SERS
human skin
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Summary:Surface-enhanced Raman spectroscopy (SERS) is a sensitive, chemically specific, and short-time response probing method with significant potential in biomedical sensing. This paper reports the integration of SERS with microneedle arrays as a minimally invasive platform for chemical sensing, with a particular view toward sensing in interstitial fluid (ISF). Microneedle arrays were fabricated from a commercial polymeric adhesive and coated with plasmonically active gold nanorods that were functionalized with the pH-sensitive molecule 4-mercaptobenzoic acid. This sensor can quantitate pH over a range of 5 to 9 and can detect pH levels in an agar gel skin phantom and in human skin in situ. The sensor array is stable and mechanically robust in that it exhibits no loss in SERS activity after multiple punches through an agar gel skin phantom and human skin or after a month-long incubation in phosphate-buffered saline. This work is the first to integrate SERS-active nanoparticles with polymeric microneedle arrays and to demonstrate in situ sensing with this platform.
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J.P. and N.Y.-T. contributed equally with designing and conducting the experiments, characterizing the sensor, and analyzing the data. E.V.E. and A.-I.H. mentored and supported with many fruitful discussions to develop this work. A.-I.H. contributed to the general direction of the project and helped put the project together. B.E.P.W. helped facilitate experiments on human skin through experimental design. A.-I.H., M.M. and R.P.V.D. supervised the experimental aspect and the direction of the project.
(R.P.V.D.) Died July 28, 2019.
Author Contributions
ISSN:1530-6984
1530-6992
DOI:10.1021/acs.nanolett.9b02070