Bioactive Diterpenes from Orthosiphon labiatus and Salvia africana-lutea

• Published in: Journal of natural products (Washington, D.C.) Vol. 70; no. 2; pp. 293 - 295
• Main Authors: Hussein, Ahmed A, Meyer, Jacobus J. M, Jimeno, María L, Rodríguez, Benjamín
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.02.2007; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Antitubercular Agents - chemistry; Antitubercular Agents - isolation & purification; Antitubercular Agents - pharmacology; Biological and medical sciences; Chemistry, Medicinal; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; Drug Screening Assays, Antitumor; Female; General pharmacology; Humans; Inhibitory Concentration 50; Life Sciences & Biomedicine; Medical sciences; Molecular Structure; Mycobacterium tuberculosis - drug effects; Orthosiphon - chemistry; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Plants, Medicinal - chemistry; Salvia - chemistry; Science & Technology; FAMILY LABIATAE; ROSMARINUS-OFFICINALIS; INHIBITION; ACIDS; STAMINEUS; LABDANE; DERIVATIVES; H-1; ASSIGNMENTS; CONSTITUENTS; Cytotoxicity; Extract; NMR spectrometry; Medicinal plant; Dicotyledones; Angiospermae; Bacteria; Aromatic compound; Mammary gland; Labdane derivatives; Tumor cell; Human; Terpenoid; Diol; Ethanol; Pharmacognosy; In vitro; Biological activity; Two dimension spectrometry; Cell line; Mycobacterium tuberculosis; Labiatae; Mycobacteriales; Plant origin; Mycobacteriaceae; Diterpene; Isolation; Active ingredient; Actinomycetes; Spermatophyta; Salvia; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0680376

The known (+)-trans-ozic acid (1) and two new labdane diterpenoids (2 and 3) have been isolated from an ethanol extract of Orthosiphon labiatus. The structures of 2 and 3 were established mainly by 1D and 2D NMR spectroscopic means. The ethanolic extract of Salvia africana-lutea afforded the known abietane diterpenoids carnosol (4), rosmadial (5), and carnosic acid (characterized as its derivative 6). Compounds 3 and 6 exhibited MICs of 157 and 28 μM, respectively, against Mycobacterium tuberculosis, while 2 and 6 showed cytotoxic activity with IC50 82 and 69 μM, respectively, against a breast (MCF-7) human cancer cell line.