Room Temperature Palladium-Catalyzed Intramolecular Hydroamination of Unactivated Alkenes
A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes is described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. The formation of hydroamination products rather than oxidative amination products...
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Published in | Journal of the American Chemical Society Vol. 128; no. 13; pp. 4246 - 4247 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
05.04.2006
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes is described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. The formation of hydroamination products rather than oxidative amination products is due to the use of a tridentate ligand on Pd which effectively inhibits β-hydride elimination. |
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Bibliography: | istex:0E1F4EBBB37B2E6DBE96055A218A53B229FE1F0B ark:/67375/TPS-3DNVH5JW-W ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0002-7863 1520-5126 |
DOI: | 10.1021/ja060126h |