Magnesium Ion Selective Two-Photon Fluorescent Probe Based on a Benzo[h]chromene Derivative for in Vivo Imaging

A novel, two-photon probe for the detection of free Mg2+ ions in living cells and live tissues has been developed. The probe can be excited by 880 nm laser photons, emits strong two-photon excited fluorescence in response to Mg2+ ions, can be easily loaded into the cell and tissue, shows high photos...

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Published inJournal of organic chemistry Vol. 72; no. 6; pp. 2088 - 2096
Main Authors Kim, Hwan Myung, Yang, Pil Rye, Seo, Mun Sik, Yi, Jae-Sung, Hong, Jin Hee, Jeon, Seung-Joon, Ko, Young-Gyu, Lee, Kyoung J, Cho, Bong Rae
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 16.03.2007
Amer Chemical Soc
Subjects
Animals
Benzopyrans
Cells - chemistry
Chemistry
Chemistry, Organic
Exact sciences and technology
Fluorescent Dyes
Heterocyclic compounds
Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
Humans
Magnesium - analysis
Magnesium - pharmacokinetics
Organic chemistry
Photons
Physical Sciences
Preparations and properties
Science & Technology
CROSS-SECTIONS
NMR
FLUOROPHORES
CALCIUM
SENSOR
MG2
METAL-IONS
MICROSCOPY
MODULATION
ABSORPTION PROPERTIES
In vivo
Calcium ion
Imaging
Laser
Magnesium ion
Fluorescence
Dissociation constant
Selectivity
Fluorescent compound
Detection
Oxygen heterocycle
Online AccessGet full text

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Abstract A novel, two-photon probe for the detection of free Mg2+ ions in living cells and live tissues has been developed. The probe can be excited by 880 nm laser photons, emits strong two-photon excited fluorescence in response to Mg2+ ions, can be easily loaded into the cell and tissue, shows high photostability, and can measure the Mg2+ ion concentration without interference by Ca2+ ions in living cells. The intracellular dissociation constant (K d i) for Mg2+ determined by the two-photon process is 2.5 mM, which is suitable for dynamic Mg2+ concentration measurement. In addition, the probe is capable of imaging endogenous stores of free Mg2+ at a few hundred micrometers depth in live tissues using two-photon microscopy (TPM).
AbstractList A novel, two-photon probe for the detection of free Mg2+ ions in living cells and live tissues has been developed. The probe can be excited by 880 nm laser photons, emits strong two-photon excited fluorescence in response to Mg2+ ions, can be easily loaded into the cell and tissue, shows high photostability, and can measure the Mg2+ ion concentration without interference by Ca2+ ions in living cells. The intracellular dissociation constant (Kdi) for Mg2+ determined by the two-photon process is 2.5 mM, which is suitable for dynamic Mg2+ concentration measurement. In addition, the probe is capable of imaging endogenous stores of free Mg2+ at a few hundred micrometers depth in live tissues using two-photon microscopy (TPM).
A novel, two-photon probe for the detection of free Mg2+ ions in living cells and live tissues has been developed. The probe can be excited by 880 nm laser photons, emits strong two-photon excited fluorescence in response to Mg2+ ions, can be easily loaded into the cell and tissue, shows high photostability, and can measure the Mg2+ ion concentration without interference by Ca2+ ions in living cells. The intracellular dissociation constant (K d i) for Mg2+ determined by the two-photon process is 2.5 mM, which is suitable for dynamic Mg2+ concentration measurement. In addition, the probe is capable of imaging endogenous stores of free Mg2+ at a few hundred micrometers depth in live tissues using two-photon microscopy (TPM).
Author Kim, Hwan Myung
Hong, Jin Hee
Seo, Mun Sik
Yang, Pil Rye
Ko, Young-Gyu
Cho, Bong Rae
Yi, Jae-Sung
Jeon, Seung-Joon
Lee, Kyoung J
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  givenname: Hwan Myung
  surname: Kim
  fullname: Kim, Hwan Myung
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  givenname: Pil Rye
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  givenname: Mun Sik
  surname: Seo
  fullname: Seo, Mun Sik
– sequence: 4
  givenname: Jae-Sung
  surname: Yi
  fullname: Yi, Jae-Sung
– sequence: 5
  givenname: Jin Hee
  surname: Hong
  fullname: Hong, Jin Hee
– sequence: 6
  givenname: Seung-Joon
  surname: Jeon
  fullname: Jeon, Seung-Joon
– sequence: 7
  givenname: Young-Gyu
  surname: Ko
  fullname: Ko, Young-Gyu
– sequence: 8
  givenname: Kyoung J
  surname: Lee
  fullname: Lee, Kyoung J
– sequence: 9
  givenname: Bong Rae
  surname: Cho
  fullname: Cho, Bong Rae
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https://www.ncbi.nlm.nih.gov/pubmed/17316048$$D View this record in MEDLINE/PubMed
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Keywords CROSS-SECTIONS
NMR
FLUOROPHORES
CALCIUM
SENSOR
MG2
METAL-IONS
MICROSCOPY
MODULATION
ABSORPTION PROPERTIES
In vivo
Calcium ion
Imaging
Laser
Magnesium ion
Fluorescence
Dissociation constant
Selectivity
Fluorescent compound
Detection
Oxygen heterocycle
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Snippet A novel, two-photon probe for the detection of free Mg2+ ions in living cells and live tissues has been developed. The probe can be excited by 880 nm laser...
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SubjectTerms Animals
Benzopyrans
Cells - chemistry
Chemistry
Chemistry, Organic
Exact sciences and technology
Fluorescent Dyes
Heterocyclic compounds
Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
Humans
Magnesium - analysis
Magnesium - pharmacokinetics
Organic chemistry
Photons
Physical Sciences
Preparations and properties
Science & Technology
Title Magnesium Ion Selective Two-Photon Fluorescent Probe Based on a Benzo[h]chromene Derivative for in Vivo Imaging
URI http://dx.doi.org/10.1021/jo062341m
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