Human Listeriosis

Listeria monocytogenes is a Gram-positive facultative intracellular pathogen that can cause severe invasive infections upon ingestion with contaminated food. Clinically, listerial disease, or listeriosis, most often presents as bacteremia, meningitis or meningoencephalitis, and pregnancy-associated...

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Published inClinical microbiology reviews Vol. 36; no. 1; p. e0006019
Main Authors Koopmans, Merel M, Brouwer, Matthijs C, Vázquez-Boland, José A, van de Beek, Diederik
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 23.03.2023
Subjects
Bacteremia
Clinical Microbiology
Female
Food Microbiology
Humans
Infant, Newborn
Listeria monocytogenes - genetics
Listeriosis - epidemiology
Listeriosis - microbiology
Listeriosis - prevention & control
Pregnancy
Review
Risk Factors
epidemiology
neurolisteriosis
listeriosis
pathophysiology
Listeria monocytogenes
bacterial genetics
histopathology
pregnancy-related listeriosis
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Summary:Listeria monocytogenes is a Gram-positive facultative intracellular pathogen that can cause severe invasive infections upon ingestion with contaminated food. Clinically, listerial disease, or listeriosis, most often presents as bacteremia, meningitis or meningoencephalitis, and pregnancy-associated infections manifesting as miscarriage or neonatal sepsis. Invasive listeriosis is life-threatening and a main cause of foodborne illness leading to hospital admissions in Western countries. Sources of contamination can be identified through international surveillance systems for foodborne bacteria and strains' genetic data sharing. Large-scale whole genome studies have increased our knowledge on the diversity and evolution of L. monocytogenes, while recent pathophysiological investigations have improved our mechanistic understanding of listeriosis. In this article, we present an overview of human listeriosis with particular focus on relevant features of the causative bacterium, epidemiology, risk groups, pathogenesis, clinical manifestations, and treatment and prevention.
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Diederik van de Beek and José A. Vázquez-Boland contributed equally to this article and share senior authorship.
The authors declare no conflict of interest.
ISSN:0893-8512
1098-6618
DOI:10.1128/cmr.00060-19