Technologies for micromanipulating, imaging, and phenotyping small invertebrates and vertebrates

Small multicellular model organisms such as the invertebrate nematode C. elegans and the vertebrate zebrafish provide unique opportunities for both basic science and pharmaceutical discovery. In recent years, there have been significant breakthroughs in technologies to manipulate and image these org...

Full description

Saved in:
Bibliographic Details
Published inAnnual review of biomedical engineering Vol. 13; p. 185
Main Authors Yanik, Mehmet Fatih, Rohde, Christopher B, Pardo-Martin, Carlos
Format Journal Article
LanguageEnglish
Published United States 15.08.2011
Subjects
Animals
Caenorhabditis elegans - cytology
Caenorhabditis elegans - embryology
Caenorhabditis elegans - physiology
Flow Cytometry - instrumentation
High-Throughput Screening Assays - instrumentation
High-Throughput Screening Assays - methods
Humans
Imaging, Three-Dimensional - instrumentation
Microfluidic Analytical Techniques
Microfluidics - instrumentation
Microfluidics - methods
Micromanipulation - instrumentation
Micromanipulation - methods
Microscopy, Confocal - instrumentation
Molecular Imaging - instrumentation
Phenotype
Zebrafish - embryology
Zebrafish - physiology
Online AccessGet more information

Cover

More Information
Summary:Small multicellular model organisms such as the invertebrate nematode C. elegans and the vertebrate zebrafish provide unique opportunities for both basic science and pharmaceutical discovery. In recent years, there have been significant breakthroughs in technologies to manipulate and image these organisms for a variety of purposes ranging from behavioral studies of neuronal circuits to high-throughput screening. Here, we review these advancements with a particular focus on the optically transparent model organisms C. elegans and zebrafish.
ISSN:1545-4274
DOI:10.1146/annurev-bioeng-071910-124703