Antioxidant Activity of Chemical Components from Sage (Salvia officinalis L.) and Thyme (Thymus vulgaris L.) Measured by the Oil Stability Index Method

• Published in: Journal of agricultural and food chemistry Vol. 50; no. 7; pp. 1845 - 1851
• Main Authors: Miura, Kayoko, Kikuzaki, Hiroe, Nakatani, Nobuji
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 27.03.2002; Amer Chemical Soc
• Subjects: Agriculture; Agriculture, Multidisciplinary; Agronomy. Soil science and plant productions; Anthraquinones - analysis; Antioxidants - analysis; Antioxidants - pharmacology; Biological and medical sciences; Chemical constitution; Chemistry; Chemistry, Applied; Diterpenes - analysis; Drug Stability; Economic plant physiology; Flavonoids - analysis; Food additives; Food industries; Food Science & Technology; Free Radical Scavengers; Fundamental and applied biological sciences. Psychology; General aspects; Life Sciences & Biomedicine; Oils; Physical Sciences; Plant Extracts - analysis; Plant Extracts - pharmacology; Plant Leaves - chemistry; Salvia officinalis - chemistry; Science & Technology; Silicones; Terpenes - analysis; Thymus Plant - chemistry; ELUCIDATION; CARNOSIC ACID; FAMILY LABIATAE; apianane terpenoid; abietane diterpenoid; OSI; TERPENOIDS; thyme; Salvia officinalis L; oil stability index; Thymus vulgaris L; ROSMARINUS-OFFICINALIS; ROSEMARY; PHENOLIC DITERPENES; sage; antioxidative activity; 12-O-methyl carnosol; flavonoid; EXTRACTS; DPPH radical scavenging activity; CONSTITUENTS; FLAVONES; Terpenoid; Anthraquinone derivatives; Stability; Food additive; Thymus vulgaris; Antioxidant; Flavonoid; Radical scavenger; Biological activity; Oil; Labiatae; Dicotyledones; Salvia officinalis; Angiospermae; Diterpene; Flavoring crop; Isolation; Spermatophyta; Chemical composition; Measurement method; Oil stability index
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf011314o

A new abietane diterpenoid, 12-O-methyl carnosol (2), was isolated from the leaves of sage (Salvia officinalis L.), together with 11 abietane diterpenoids, 3 apianane terpenoids, 1 anthraquinone, and 8 flavonoids. Antioxidant activity of these compounds along with 4 flavonoids isolated from thyme (Thymus vulgaris L.) was evaluated by the oil stability index method using a model substrate oil including methyl linoleate in silicone oil at 90 °C. Carnosol, rosmanol, epirosmanol, isorosmanol, galdosol, and carnosic acid exhibited remarkably strong activity, which was comparable to that of α-tocopherol. The activity of miltirone, atuntzensin A, luteolin, 7-O-methyl luteolin, and eupafolin was comparable to that of butylated hydroxytoluene. The activity of these compounds was mainly due to the presence of ortho-dihydroxy groups. The 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of these compounds showed the similar result. Keywords: Salvia officinalis L.; sage; Thymus vulgaris L.; thyme; 12-O-methyl carnosol; apianane terpenoid; abietane diterpenoid; flavonoid; antioxidative activity; oil stability index; OSI; DPPH radical scavenging activity