Chemical Exchanges between Multilateral Symbionts

Herein is a report on the molecular exchange occurring between multilateral symbiosis partnersa tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrome...

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Published inOrganic letters Vol. 23; no. 5; pp. 1648 - 1652
Main Authors Bae, Munhyung, Mevers, Emily, Pishchany, Gleb, Whaley, Sarah G, Rock, Charles O, Andes, David R, Currie, Cameron R, Pupo, Monica T, Clardy, Jon
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 05.03.2021
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Herein is a report on the molecular exchange occurring between multilateral symbiosis partnersa tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.
Bibliography:FAPESP
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M.B., E.M, G.P., and S.G.W. performed the experiments. M.B., E.M., and J.C. wrote the manuscript. J.C., C.O.R., D.R.A., C.R.C., and M.T.P. guided the study. All authors read, revised, and approved the manuscript.
Author Contributions
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c00068