Cytotoxic Prenylated Xanthones and the Unusual Compounds Anthraquinobenzophenones from Cratoxylum sumatranum

• Published in: Journal of natural products (Washington, D.C.) Vol. 65; no. 3; pp. 299 - 305
• Main Authors: Seo, Eun-Kyoung, Kim, Nam-Cheol, Wani, Mansukh C, Wall, Monroe E, Navarro, Hernán A, Burgess, Jason P, Kawanishi, Kazuko, Kardono, Leonardus B. S, Riswan, Soedarsono, Rose, William C, Fairchild, Craig R, Farnsworth, Norman R, Kinghorn, A. Douglas
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.03.2002; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Animals; Anthracenes - chemistry; Anthracenes - isolation & purification; Anthracenes - pharmacology; Anthraquinones - chemistry; Anthraquinones - isolation & purification; Anthraquinones - pharmacology; Benzophenones - chemistry; Benzophenones - isolation & purification; Benzophenones - pharmacology; Biological and medical sciences; Chemistry, Medicinal; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; General pharmacology; Humans; Indonesia; KB Cells - drug effects; Leukemia P388; Life Sciences & Biomedicine; Medical sciences; Mice; Mice, Inbred DBA; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Bark - chemistry; Plant Leaves - chemistry; Plant Sciences; Plant Stems - chemistry; Plants, Medicinal - chemistry; Science & Technology; Tumor Cells, Cultured - drug effects; Vitamin E - analogs & derivatives; Vitamin E - chemistry; Vitamin E - isolation & purification; Vitamin E - pharmacology; Xanthenes - chemistry; Xanthenes - isolation & purification; Xanthones; Asia; Indonesia; TOCOTRIENOLS; ROOTS; CEYLONESE PLANTS; BARK; CONSTITUENTS; EXTRACTIVES; Antineoplastic agent; Benzophenone derivatives; Bark; Cytotoxicity; Oxygen heterocycle; Stem; Medicinal plant; Polyphenol; Aromatic compound; Tumor cell; Human; Anthraquinone derivatives; Pharmacognosy; Quinone; Plant leaf; Tetracyclic compound; Tricyclic compound; Isoprenoid; Condensed benzenic compound; In vitro; Biological activity; Ketophenols; Cell line; KB cell line; Plant origin; Isolation; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np010395f

Six new xanthones, cratoxyarborenones A−F (1−6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and δ-tocotrienol, were obtained as inactive constituents.