A Direct Catalytic Asymmetric Mannich-type Reaction to syn-Amino Alcohols

The Mannich reaction is one of the most widely utilized chemical transformations for the construction of nitrogen-containing compounds. With the increasing occurrence of nitrogen in drugs and natural products, highly asymmetric variants of the Mannich reaction are desirable. In this communication, w...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 125; no. 2; pp. 338 - 339
Main Authors Trost, Barry M, Terrell, Lamont R
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 15.01.2003
Amer Chemical Soc
Subjects
Amino Alcohols - chemistry
Catalysis
Chemistry
Chemistry, Multidisciplinary
Exact sciences and technology
Imines - chemistry
Ketones - chemistry
Organic chemistry
Physical Sciences
Science & Technology
Stereoisomerism
Zinc - chemistry
ALLIBIS(BINAPHTHOXIDE) COMPLEX
BETA-AMINO
LA(OTF)CENTER-DOT-NHO
UNMODIFIED KETONES
ACID-ESTERS
IMINES
Catalytic reaction
Aliphatic compound
Catalyst selectivity
Transition metal Complexes
Complex catalyst
Experimental study
Diastereoselectivity
Aldimine
Mannich reaction
Asymmetric reaction
Ketimine
Benzenic compound
Zinc Complexes
Catalyst activity
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Summary:The Mannich reaction is one of the most widely utilized chemical transformations for the construction of nitrogen-containing compounds. With the increasing occurrence of nitrogen in drugs and natural products, highly asymmetric variants of the Mannich reaction are desirable. In this communication, we report the application of our dinuclear zinc catalyst to a highly asymmetric Mannich-type reaction to generate syn 1,2-amino alcohols.
Bibliography:ark:/67375/TPS-8SQ7RWPJ-W
istex:76DA7C17047F91449ABFA52AC9C8768301CB4964
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-7863
1520-5126
DOI:10.1021/ja028782e