Aptamer-Based Colorimetric Probe for Cocaine

• Published in: Journal of the American Chemical Society Vol. 124; no. 33; pp. 9678 - 9679
• Main Authors: Stojanovic, Milan N, Landry, Donald W
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 21.08.2002
• Subjects: Analytical chemistry; Base Sequence; Carbocyanines - chemistry; Chemistry; Cocaine - analysis; Cocaine - chemistry; Colorimetry - methods; Coloring Agents - chemistry; Exact sciences and technology; Miscellaneous; Molecular Sequence Data; Oligonucleotides - chemistry; Spectrophotometry - methods; Chemistry; Cocaine; Colorimetry

Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a colorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2−600 μM. Mechanistic studies indicate an intermolecular displacement of the dye as the mechanism of action of...