Type IV pilus retraction is required for Neisseria musculi colonization and persistence in a natural mouse model of infection

• Published in: mBio Vol. 15; no. 1; p. e0279223
• Main Authors: Rhodes, Katherine A, Rendón, María A, Ma, Man Cheong, Agellon, Al, Johnson, Andrew C E, So, Magdalene
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 16.01.2024
• Subjects: Animals; Bacterial Proteins; Fimbriae Proteins; Fimbriae, Bacterial; Host-Microbial Interactions; Humans; Mice; Neisseria - genetics; Neisseria gonorrhoeae; Neisseria musculi; PilT; PilT2; PilU; Research Article; Symbiosis; Type IV pilus retraction; Neisseria gonorrhoeae; PilT; colonization; Type IV pilus retraction; commensal Neisseria; PilU; PilT2; persistence; Neisseria meningitidis; Neisseria musculi

We describe the importance of Type IV pilus retraction to colonization and persistence by a mouse commensal in its native host. Our findings have implications for the role of Tfp retraction in mediating interactions of human-adapted pathogenic and commensal with their human host due to the relatedne...