Type IV pilus retraction is required for Neisseria musculi colonization and persistence in a natural mouse model of infection

We describe the importance of Type IV pilus retraction to colonization and persistence by a mouse commensal in its native host. Our findings have implications for the role of Tfp retraction in mediating interactions of human-adapted pathogenic and commensal with their human host due to the relatedne...

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Published inmBio Vol. 15; no. 1; p. e0279223
Main Authors Rhodes, Katherine A, Rendón, María A, Ma, Man Cheong, Agellon, Al, Johnson, Andrew C E, So, Magdalene
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 16.01.2024
Subjects
Animals
Bacterial Proteins
Fimbriae Proteins
Fimbriae, Bacterial
Host-Microbial Interactions
Humans
Mice
Neisseria - genetics
Neisseria gonorrhoeae
Neisseria musculi
PilT
PilT2
PilU
Research Article
Symbiosis
Type IV pilus retraction
Neisseria gonorrhoeae
PilT
colonization
Type IV pilus retraction
commensal Neisseria
PilU
PilT2
persistence
Neisseria meningitidis
Neisseria musculi
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Summary:We describe the importance of Type IV pilus retraction to colonization and persistence by a mouse commensal in its native host. Our findings have implications for the role of Tfp retraction in mediating interactions of human-adapted pathogenic and commensal with their human host due to the relatedness of these species.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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The authors declare no conflict of interest.
Present address: Boehringer Ingelheim, Fremont, California, USA
ISSN:2150-7511
2150-7511
DOI:10.1128/mbio.02792-23