Formal Enone α‑Arylation via I(III)-Mediated Aryl Migration/Elimination

A formal enone α-arylation is described. This metal-free transformation relies on the I­(III)-mediated skeletal reorganization of silyl enol ethers and features mild conditions, good yields, and high stereoselectivities for β-substituted enones.

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Bibliographic Details
Published inOrganic letters Vol. 23; no. 6; pp. 2094 - 2098
Main Authors Martins, Bruna S, Kaiser, Daniel, Bauer, Adriano, Tiefenbrunner, Irmgard, Maulide, Nuno
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 19.03.2021
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Letter
Physical Sciences
Science & Technology
KETONES
METAL-FREE ARYLATION
OXYALLYL CATION CAPTURE
IODINE(III) REAGENTS
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Summary:A formal enone α-arylation is described. This metal-free transformation relies on the I­(III)-mediated skeletal reorganization of silyl enol ethers and features mild conditions, good yields, and high stereoselectivities for β-substituted enones.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c00251