Abnormalities of regional distribution of cerebral vasculature in schizophrenia detected by dynamic susceptibility contrast MRI

The authors tested the hypothesis that the regional distribution of cerebral vasculature is anomalous in schizophrenia. Dynamic susceptibility contrast magnetic resonance imaging was used to evaluate cerebral blood volume in the right and left occipital cortex, basal ganglia, and cerebellum of 10 su...

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Bibliographic Details
Published inThe American journal of psychiatry Vol. 152; no. 12; p. 1801
Main Authors Cohen, B M, Yurgelun-Todd, D, English, C D, Renshaw, P F
Format Journal Article
LanguageEnglish
Published United States 01.12.1995
Subjects
Adult
Basal Ganglia - blood supply
Blood Vessels - physiopathology
Cerebellum - blood supply
Cerebrovascular Circulation
Echo-Planar Imaging
Female
Functional Laterality
Gadolinium
Heterocyclic Compounds
Humans
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Male
Occipital Lobe - blood supply
Organometallic Compounds
Schizophrenia - diagnosis
Schizophrenia - physiopathology
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Summary:The authors tested the hypothesis that the regional distribution of cerebral vasculature is anomalous in schizophrenia. Dynamic susceptibility contrast magnetic resonance imaging was used to evaluate cerebral blood volume in the right and left occipital cortex, basal ganglia, and cerebellum of 10 subjects with schizophrenia and 10 healthy comparison subjects. Cerebral blood volume was greater in the schizophrenic subjects in every region studied. The findings suggest an abnormality of the configuration of cerebral blood vessels in schizophrenia.
ISSN:0002-953X
DOI:10.1176/ajp.152.12.1801