Fluorinated Phosphonates:  Synthesis and Biomedical Application

The chemistry of fluorinated alykylphosphonates is a relatively new area of research, developed mostly over the last two decades. The synthesis, fundamental chemical properties, and biomedical uses of the phosphonic acid derivatives that bear at least one fluorine substituent on the organyl moiety a...

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Bibliographic Details
Published inChemical reviews Vol. 106; no. 9; pp. 3868 - 3935
Main Authors Romanenko, Vadim D, Kukhar, Valery P
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.09.2006
Subjects
Antibodies - chemistry
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Biomedical research
Catalysis
Chemical synthesis
Chemistry
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Hydrocarbons, Fluorinated - chemistry
Inhibitor drugs
Molecular Structure
Organophosphonates - chemical synthesis
Organophosphonates - chemistry
Organophosphonates - pharmacology
Platelet Aggregation Inhibitors - chemical synthesis
Platelet Aggregation Inhibitors - chemistry
Platelet Aggregation Inhibitors - pharmacology
Stereoisomerism
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Summary:The chemistry of fluorinated alykylphosphonates is a relatively new area of research, developed mostly over the last two decades. The synthesis, fundamental chemical properties, and biomedical uses of the phosphonic acid derivatives that bear at least one fluorine substituent on the organyl moiety are the subject of this review.
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ark:/67375/TPS-7V9BF24Q-D
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0009-2665
1520-6890
DOI:10.1021/cr051000q