Rifampin Resistance in Staphylococci after Rifaximin Intake for Surgical Prophylaxis in Elective Colorectal Surgery

The aim of our study was to determine whether rifampin resistance emerges in human skin staphylococci after oral intake of rifaximin for surgical prophylaxis. Rifampin-resistant staphylococci appeared on the skin of 32 out of 74 patients (43.2%) two weeks after prophylactic treatment with rifaximin....

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Published inAntimicrobial agents and chemotherapy Vol. 62; no. 12
Main Authors Padilla, Emma, Oms, Lluis, Espejo, Elena, Gómez, Laura, Pagespetit, Lurdes, Boada, Núria, Bella, Feliu, Pérez, Josefa
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.12.2018
Subjects
Antibiotic Prophylaxis
Rifampin
Rifaximin
Staphylococcal Infections
Staphylococcus
Susceptibility
antibiotic resistance
rifaximin
surgical prophylaxis
rifampin
Staphylococcus
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Summary:The aim of our study was to determine whether rifampin resistance emerges in human skin staphylococci after oral intake of rifaximin for surgical prophylaxis. Rifampin-resistant staphylococci appeared on the skin of 32 out of 74 patients (43.2%) two weeks after prophylactic treatment with rifaximin. In all cases, the resistant strains were coagulase-negative staphylococci. The resistance completely reverted after three months. This study shows the emergence of transient resistance to rifampin after rifaximin intake.
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Citation Padilla E, Oms L, Espejo E, Gómez L, Pagespetit L, Boada N, Bella F, Pérez J. 2018. Rifampin resistance in staphylococci after rifaximin intake for surgical prophylaxis in elective colorectal surgery. Antimicrob Agents Chemother 62:e01353-18. https://doi.org/10.1128/AAC.01353-18.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01353-18