Cycloisomerization between Aryl Enol Ether and Silylalkynes under Ruthenium Hydride Catalysis: Synthesis of 2,3-Disubstituted Benzofurans

Metal-catalyzed cycloisomerization reactions of 1,n-enynes have become conceptually and chemically attractive processes in the search for atom economy, which is a key subject of current research. However, metal-catalyzed cycloisomerization between aryl enol ether and silylalkynes has not been develo...

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Published inOrganic letters Vol. 19; no. 9; pp. 2422 - 2425
Main Authors Ohno, Shohei, Takamoto, Kohei, Fujioka, Hiromichi, Arisawa, Mitsuhiro
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 05.05.2017
Amer Chemical Soc
Subjects
benzofurans
catalytic activity
chemical reactions
Chemistry
Chemistry, Organic
enol ethers
hydrides
moieties
Physical Sciences
ruthenium
Science & Technology
GOLD
CARBENE
COMPLEX
ISOMERIZATION
NITROGEN
CYCLIZATION
VINYL ETHERS
1,N-ENYNES
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Summary:Metal-catalyzed cycloisomerization reactions of 1,n-enynes have become conceptually and chemically attractive processes in the search for atom economy, which is a key subject of current research. However, metal-catalyzed cycloisomerization between aryl enol ether and silylalkynes has not been developed. The ruthenium hydride complex catalyzed cycloisomerization between aryl enol ether and silylalkynes is reported to give benzofurans having useful functional groups, vinyl and trimethylsilylmethyl, on the 2- and 3-positions, respectively.
Bibliography:KAKEN
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.7b00985