Artificial Peptide-Nanospheres Self-Assembled from Three-Way Junctions of β-Sheet-Forming Peptides

• Published in: Journal of the American Chemical Society Vol. 127; no. 29; pp. 10148 - 10149
• Main Authors: Matsuura, Kazunori, Murasato, Kazuya, Kimizuka, Nobuo
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 27.07.2005; Amer Chemical Soc
• Subjects: Biological and medical sciences; Chemistry; Chemistry, Multidisciplinary; Circular Dichroism; Fundamental and applied biological sciences. Psychology; Interactions. Associations; Intermolecular phenomena; Microscopy, Atomic Force; Models, Molecular; Molecular biophysics; Nanotubes - chemistry; Oligopeptides - chemistry; Physical Sciences; Protein Structure, Secondary; Science & Technology; NANOPARTICLES; DESIGN; CAGE; FIBRILS; AMPHIPHILES; CLATHRIN; Atomic force microscopy; Supramolecular structure; Biopolymer; Molecular association; Molecular interaction; Molecular aggregation; Nanosphere; Polyaminoacid; Amphiphilic polymer
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja052644i

Rational design of self-assembly of proteins, which plays pivotal roles in biology, is an important subject for biotechnology and also bottom-up nanotechnology. This paper has proposed a novel strategy for construction of artificial peptide-nanospheres by self-assembly. Mimicking formation of spherical viruses and clathrin, we designed a novel C 3-symmetric peptide conjugate bearing three β-sheet-forming peptides. These peptide conjugates formed antiparallel β-structures and self-assembled into nanospheres with the size of about 20 nm in the acidic solution.