Specific Antioxidant Activity of Caffeoyl Derivatives and Other Natural Phenolic Compounds: LDL Protection against Oxidation and Decrease in the Proinflammatory Lysophosphatidylcholine Production

• Published in: Journal of natural products (Washington, D.C.) Vol. 64; no. 4; pp. 480 - 486
• Main Authors: Cartron, Emeline, Carbonneau, Marie-Annette, Fouret, Gilles, Descomps, Bernard, Léger, Claude L
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.04.2001; Glendale, AZ American Society of Pharmacognosy
• Subjects: Antioxidants - pharmacology; Biological and medical sciences; Caffeic Acids - pharmacology; Coffee, tea and other stimulative beverage industries; Food industries; Fundamental and applied biological sciences. Psychology; General and cellular metabolism. Vitamins; General pharmacology; Humans; Inflammation Mediators - metabolism; Lipoproteins, LDL - blood; Lysophosphatidylcholines - biosynthesis; Medical sciences; Oxidation-Reduction; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phenols - pharmacology; Catechin; Phenolic acid; Epimer; Coffee bean; Olive oil; Antioxidant; Red wine; Flavonoid; Biological activity; Lysophosphatidylcholine; Benzoic acid derivatives; Lipoprotein LDL; Prevention; Polyphenol; Plant origin; Lysophospholipid; Oxidation; Peroxidation
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np000421u

Specific antioxidant activity (SAA) (i.e., activity related to the molar or gallic acid equivalent amount of antioxidant) of natural polyphenolic mixtures or pure phenolic compounds was studied using their capacity to delay the conjugated diene production brought about by in vitro LDL copper-mediated or AAPH-mediated oxidation. The cinnamic acid series (caffeic, sinapic, ferulic acids) displayed a constant SAA over a large range of concentrations, whereas the benzoic acid series (gallic and protocatechuic acids) showed much higher SAA at low concentrations. The natural phenolic mixtures had a constant SAA. The highest SAA was obtained with caffeoyl esters (caffeoylquinic, rosmarinic, and caffeoyltartaric acids) and catechin for the copper-oxidation and the AAPH-oxidation system, respectively. Phenolic mixtures and acids delayed vitamin E depletion and decreased proinflammatory lysophosphatidylcholine production. As with polyphenols, probucol delayed lysophosphatidylcholine and conjugated dienes production, at higher concentrations, but was not effective at preventing vitamin E depletion. Polyphenols prevent the oxidation of LDL and its constituents (vitamin E, phosphatidylcholine), which is compatible with an antiinflammatory and antiatherosclerotic role in pathophysiological conditions.